東京工業大学 生命理工学研究科 丸山研究室
Maruyama Laboratory

論文リストSERVICE&PRODUCTS

20192018201720162015201420132012201120102009200820072006200520042003200220012000199919981997

2019年
  • O. Hanpanich, H. Miyaguchi, H. Huang, N. Shimada, A. Maruyama, Cationic copolymer-chaperoned short-armed 10-23 DNAzymes Nucleosides, Nucleotides & Nucleic Acids in press (2019)
  • O. Hanpanich, T. Oyanagi, N. Shimada, A. Maruyama, Cationic copolymer-chaperoned DNAzyme sensor for microRNA detection Biomaterials 225 119535 (2019)
  • N. Shimada, H. Kinoshita, T. Umegae, S. Azumai, N. Kume, T. Ochiai, T. Takenaka, W. Sakamoto, T. Yamada, T. Furuta, T. Masuda, M. Sakurai, H. Higuchi, A. Maruyama, Cationic Copolymer‐Chaperoned 2D-3D Reversible Conversion of Lipid Membranes Adv.Mater. 31 1904032 (2019)
  • T. Masuda, N. Shimada, A. Maruyama, Liposome-Surface-Initiated ARGET ATRP: Surface Softness Generated by "Grafting from" Polymerization. Langmuir 35 5581-5586 (2019)
  • W. Sakamoto, T. Masuda, T. Ochiai, N. Shimada, A. Maruyama, Cationic Copolymers Act As Chaperones of a Membrane-Active Peptide: Influence on Membrane Selectivity. ACS Biomaterials Science & Engineering in press (2019)
  • S. Kuroyanagi, N. Shimada, S. Fujii, T. Furuta, A. Harada, K. Sakurai, A. Maruyama, Highly Ordered Polypeptide with UCST Phase Separation Behavior. J. Am. Chem. Soc.141 1261-1268 (2019)
  • B. Cheng, H. Kashida, N. Shimada, A. Maruyama, H. Asanuma, Photo-regulatable DNA isothermal amplification by template-mediated ligation. Chem. Commun. 55 1080-1083 (2019)
2018年
  • T. Miyata, N. Shimada, A. Maruyama, K. Kawai, Fluorescence Redox Blinking Adaptable to Structural Analysis of Nucleic Acids. Chem. Eur-J. 24 6755-6761 (2018)
  • N. Shimada, T. Sasaki, T. Kawano, A. Maruyama, Rational Design of UCST-type Ureido Copolymers Based on a Hydrophobic Parameter. Biomacromolecules 19 4133-4138 (2018)
  • 増田 造、丸山 厚:"スマート"な機能を持つ高分子ゲル - 先端医療・生体模倣への挑戦, 化学, vol. 73, pp. 68-69 (2018)
  • T. Masuda, N. Shimada, A. Maruyama, A Thermoresponsive Cationic Comb-Type Copolymer Enhances Membrane Disruption Activity of an Amphiphilic Peptide. Biomacromolecules 19 1333-1339 (2018)
  • N. Shimada, K. Saito, T. Miyata, H. Sato, S. Kobayashi, A. Maruyama, DNA Computing Boosted by a Cationic Copolymer. Adv. Funct. Mater. 28 1707406 (2018)
  • Y. Zhang, L. Liu, L. Lin, J. Chen, H. Tian, X. Chen, A. Maruyama, In situ Dual-crosslinked nanoparticles for tumor targeting gene delivery. Acta Biomaterialia.65 349-362 (2018)
  • H. Sato, N. Shimada, T. Masuda, A. Maruyama, Allosteric Control of Peroxidase-Mimicking DNAzyme Activity with Cationic Copolymers. Biomacromolecules 19 2082-2088 (2018)
2017年
  • K. Kawai, T. Miyata, N. Shimada, S. Ito, H. Miyasaka, A. Maruyama, Single molecule monitoring of structural switching dynamics of nucleic acids by controlling fluorescence blinking. Angew. Chem. Int. Ed.56, 15329.(2017)
  • 川井清彦、丸山 厚、蛍光blinking制御による生体分子のダイナミクス観測~KACB法.生体の科学.68 (2017)
  • 丸山厚、嶋田直彦、ソフトな高分子複合体によるバイオ分子の構造・機能制御. オレオサイエンス. 17, 41-48 (2017)
  • A. Maruyama, N. Shimada, Cationic copolymers for DNA nanobiotechnology, Synthesis and Characterization of Biorelated Polymers for Biomedical Applications, C. Scholz Ed. Wiley & Sons, Inc.. pp. 297-312 (2017)
  • H. Sato, N. Shimada, A. Maruyama,Cationic Comb-Type Copolymer Promotes DNA Assembly on Gold Nanoparticles While Enhancing Particle Dispersibility . Macromol. Res. 25, 500-503 (2017)
  • B. Cheng, H. Kashida, N. Shimada, A. Maruyama, and H. Asanuma, Chaperone-Polymer-Assisted, Photodriven DNA Strand Displacement. ChemBioChem.18, 1568-1572 (2017)
  • T. Masuda, N. Shimada, T. Sasaki, A. Maruyama, A. M. Akimoto, and R. Yoshida, , Design of a Tunable Self-Oscillating Polymer with Ureido and Ru(bpy)3 Moieties. Angew. Chem. Int. Ed.. 56, 9459-9462 (2017)
  • 畔柳 奏太朗, 丸山 厚, 嶋田 直彦 , UCST型ウレイドポリマーの調製とバイオマテリアルへの応用, 高分子論文集. Vol74, 4, 250-256 (2017)
  • W. Sakamoto, T. Ochiai, N. Shimada and A. Maruyama, Cationic copolymer augments membrane permeabilizing activity of an amphiphilic peptide J BIOMAT SCI-POLYM E.28, 1097-1108 (2017)
  • A. Yamayoshi, D. Miyoshi,Y. Zouzumi, Y. Matsuyama, J. Ariyoshi, N. Shimada, A. Murakami,T. Wada, A. Maruyama,Selective and Robust Stabilization of Triplex DNA Structures using Cationic Comb-type Copolymers J. Phys. Chem. B. 121, 4015-4022 (2017)
2016年
  • N. Shimada, M. Saito, S. Shukuri, S. Kuroyanagi, T. Kuboki, S. Kidoaki, T. Nagai, and A. Maruyama, Reversible Monolayer/Spheroid Cell Culture Switching by UCST-Type Thermoresponsive Ureido Polymers, ACS Appl. Mater. Inter. 8, 31524-31529 (2016)
  • Y. Ueda, A. Maruyama, S. Nakano, N. Sugimoto, D. Miyoshi, Effects of TMAO and urea on DNA duplex and G-quadruplex, Sci. & Tech. Adv. Mater. 17, 753-759.(2016)
  • K. Saito, N. Shimada, A. Maruyama, Cooperative enhancement of deoxyribozyme activity by chemical modification and added cationic copolymer, Sci. Tech. Adv. Mater. 17,437-442.(2016)
  • A. Fujihara, K. Itsuki, N. Shimada, A. Maruyama, N. Sagawa, T. Shikata, S. Yusa Preparation of Ureido Group Bearing Polymers and Their Upper Critical Solution Temperature in Water, J. Polym. Sci., Polym. Chem. 54, 2845-2854 (2016)
  • N. Yamaguchi, Y. Zouzumi, N. Shimada, S. Nakano, N. Sugimoto, A. Maruyama, D. Miyoshi, A reversible B?A transition of DNA duplexes induced by synthetic cationic copolymers, Chem. Commun., 52, 7446-7449 (2016)
  • Q. Liu, M, Somiya, N. Shimad, W. Sakamoto, N. Yoshimoto, M. Iijima, K. Tatematsu, T. Nakai, T. Okajima, A. Maruyama, S. Kuroda, Mutational analysis of hepatitis B virus pre-S1 (9?24) fusogenic peptide, Biochem. Biophys. Res. Commun., 474, 406-412 (2016)

2015年
  • K. Kawai, K. Higashiguchi, A. Maruyama, T. Majima, DNA microenvironment monitored by controlling redox blinking, ChemPhysChem (2015)
  • H. Lee, Y. Hoshino, Y. Wada, Y. Arata, A. Maruyama, Y. Miura, Minimization of synthetic polymer ligands for specific recognition and neutralization of a toxic peptide, J. Am. Chem. Soc. 137, 10878-10881 (2015)
  • N. Shimada, H. Kinoshita, S. Tokunaga, T. Umegae, N. Kume, W. Sakamoto, A. Maruyama, Inter-polyelectrolyte nano-assembly induces folding and activation of functional peptides, J. Controlled Release, 218, 45-52 (2015)
  • A. Fujihara, N. Shimada, A. Maruyama, K. Ishihara, K. Nakaia, S. Yusa, Preparation of upper critical solution temperature(UCST) responsive diblock copolymers bearing pendant ureido groups and their micelle formation behavior in water, Soft Matter, 11, 5204-5213 (2015)
  • J. Gao, N. Shimada, A. Maruyama, MNAzyme-catalysed nucleic acid detection enhanced by a cationic copolymer, Biomater. Sci., 3, 716-720 (2015)
  • K. Kawai, A. Maruyama, Triple helix conformation-specific blinking of Cy3 in DNA, Chem. Commun., 51, 4861-4864 (2015)
  • J. Gao, N. Shimada, A. Maruyama, Enhancement of deoxyribozyme activity by cationic copolymers, Biomater. Sci., 3, 308-316 (2015)

2014年
  • N. Shimada, S. Kidoaki, A. Maruyama, Smart hydrogels exhibiting UCST-type volume changes under physiologically relevant conditions, RSC Advances, 4, 52346-52348 (2014)
  • D. Miyoshi, Y. M. Ueda, N. Shimada, S. I. Nakano, N. Sugimoto, A. Maruyama, Drastic stabilization of parallel DNA hybridizations by a polylysine omb-type copolymer with hydrophilic graft chain, ChemMedChem., 9, 2156-63 (2014)
  • S. Yusa, M. Morihara, K. Nakai, S. Fujii, Y. Nakamura, A. Maruyama, N. Shimada, Thermo-responsive liquid marbles, Polym. J. 2013
  • K. Kawai, T. Koshino, A. Maruyama, T. Majima, Blinking Triggered by The change in the solvent accessibility of a fluorescent molecule, Chem. Commun., 50, 10478-81 (2014)
  • R. Arivazhagan, M.Endo, K. Hidaka, N. Shimada, A. Maruyama, H. Sugiyama, Lock-and-key mechanism for the controllable fabrication of DNA origami structures, Chem. Commun., 50, 8743-6 (2014)
  • A. Maruyama, N. Sonda, K. Yamasaki, M. Hirano, S. Kidoaki, N. Shimada, M. Maeshiro, M. Miyazaki, Cationic Comb-Type Copolymer Excludes Intercalating Dye from DNA Without Inducing DNA Condensation. Current Nanoscience 2014 Volume 10, 185-188 (2014)
  • N. Shimada, W. Song, and A. Maruyama, DNA Strand Exchange Reaction activated by Cationic Comb-type Copolymer Having Ureido Groups, Biomater. Sci. 2, 1480-1485 (2014)

2013年
  • J. Chen, H. Tian, X. Dong, Z. Guo, Z. Jiao, F. Li, A. Kano, A. Maruyama, X. Chen, Effective tumor treatment by VEGF siRNA complexed with hydrophobic poly(amino acid)-modified polyethylenimine, Macromol. Biosci., 13, 1438-46 (2013)
  • H. Saneyoshi, N. Shimada, A. Maruyama, Y. Ito, H. Abe, Bioorg Med Chem Lett. 23 (2013) 6851-6853.
  • N. Shimada, A. Maruyama, Thermoresponsive Polymers with Functional Groups Selected for Pharmaceutical and Biomedical Applications. 2013, 1135, 235-241.
  • A. Maruyama, N. Sonda, K. Yamasaki, S. Kidoaki, N. Shimada, M. Maeshiro, M. Miyazaki, Cationic comb-type copolymer excludes intercalating dye from DNA without inducing DNA condensation, Curr. Nanosci., Accepted.
  • A. Maruyama, N. Makita, S. W. Choi, S. Inoue, C. Lesoil, A. Yamayoshi, N. Shimada, A. Kano, T. Akaike, DNA Nanomachine chaperoned by cationic copolymers, Mater. Chem. Phys., accepted.
  •  K. Kawai, T. Majima, A. Maruyama, Detection of Single-Nucleotide Variations by Monitoring the Blinking of Fluorescence Induced by Charge Transfer in DNA, ChemBioChem., 14, 1430-1433, 2013
  • N. Shimada, M. Nakayama, A. Kano, A. Maruyama,Design of UCST Polymers for Chilling Capture of Proteins. , Biomacromolecules, 2013, 14 (5), 1452-1457 
  • J. Du, L. Wu, N. Shimada, A. Kano, A. Maruyama, Polyelectrolyte-Assisted Transconformation of Stem-loop DNA, Chem. Commun., 49, 475-477 (2013)
  • Arihiro Kano, Yuki Taniwaki, Izumi Nakamura, Naohiko Shimada, Kenji Moriyama, Atsushi Maruyama,Tumor delivery of PhotofrinR by PLL-g-PEG for photodynamic therapy.Journal of Controlled Release. , 2013, 167(3) 315-321
  • M. Nishihara, K. Imato, A. Irie, T. Kanehara, A. Kano, A. Maruyama, A. Takahara, H. Otsuka, Reversibly Cross-linked Polymeric Micelles Formed by Autonomously Exchangeable Dynamic Covalent Bonds, Chem. Lett.,42, 377-379 (2013)
  • J. Michaelis, A. Maruyama, O. Seitz, Promoting strand exchange in a DNA templated transfer reaction, Chem. Commun., 49, 618-620 (2013)
2012年
  • A. Shimoda, S. Sawada, A. Kano, A. Maruyama, A. Moquin, F. M. Winnik, K. Akiyoshi, Dual crosslinked hydrogel nanoparticles by nanogel bottom-up method for sustained-release delivery, Col. Surf., B: Biointerfaces, 99, 38-44 (2012)
  • T. Wada, A. Kano, N. Shimada, A. Maruyama, α-Amino acid pendant polymers as endosomal pH-responsive gene carriers, Macromol. Res., 20, 302-308 (2012)
  • H. Asanuma, T. Osawa, H. Kashida, T. Fujii, X. Liang, K. Niwa, Y.Yoshida, N. Shimada, A. Maruyama, A polycation-chaperoned in-stem molecular beacon system, Chem. Commun., 48, 1760 ? 1762, (2012)
  • 嶋田直彦、丸山厚、生理的条件下で作用するUCST型高分子、化学工業、63 (6), 66-70 (2012)

2011年

  • Kano, A., Moriyama, K., Yamano, T., Nakamura, I., Shimada, N., and Maruyama, A., Grafting of poly(ethylene glycol) to poly-lysine augments its lifetime in blood circulation and accumulation in tumors without loss of the ability to associate with siRNA. J Control Release, 149, 2-7 (2011)
  • R. Moriyama, N. Shimada, A. Kano, A. Maruyama, DNA assembly and re-assembly activated by cationic comb-type copolymer. Biomaterials, 32(9), 2351-2358 (2011)
  • T. Ishihara, A. Kano, K. Obara, M. Saito, X. Chen, T. G. Park, T. Akaike and A. Maruyama, Nuclear localization and antisense effect of PNA internalized by ASGP-R-mediated endocytosis with protein/DNA conjugates. J Control Release, 155, 34-39 (2011)
  • N. Sonda, M. Hirano, N. Shimada, A. Kano, S. Kidoaki and A. Maruyama, Cationic Comb-type Copolymers Do Not Cause Collapse but Shrinkage of DNA Molecules. Chemistry Letters, 40, 250-251 (2011)
  • R. Moriyama, N. Shimada, A. Kano, A. Maruyama, The Role of Cationic Comb-type Copolymers in Chaperoning DNA Annealing. Biomaterials, 32, 7671-7676 (2011)
  • N. Shimada, H. Ino, K. Maie, M. Nakayama, A. Kano, A. Maruyama, Ureido-Derivatized Polymers Based on Both Poly(allylurea) and Poly(L-citrulline) Exhibit UCST-Type Phase Transition Behavior under Physiologically Relevant Conditions. Biomacromolecules, 10(12), 3418-3422 (2011)
  • P. L. T. Tran, R. Moriyama, A. Maruyama, B. Rayner and J. L. Mergny, A mirror-image tetramolecular DNA quadruplex. Chem. Comm., 47(19), 5437-5439 (2011)
  • Moriyama R., Mochida J., Yamayoshi A., Shimada N., Kano A., Maruyama A, Preparation of Cationic Comb-Type Copolymer Having Tetra-Alkylammonium Groups and its Interaction with DNA. Curr Nanosci., 7, 979-983 (2011).

2010年

  • M. R. Berber, H. Mori, I. H. Hafez, K. Minagawa, M. Tanaka, T. Niidome, Y. Katayama, A. Maruyama, T. Hirano, Y. Maeda and T. Mori, Unusually Large Hysteresis of Temperature-Responsive Poly(N-ethyl-2-propionamidoacrylamide) Studied by Microcalorimetry and FT-IR. J. Phys. Chem. B, 114(23), 7784-7790 (2010)
  • Shimada, N., Yamamoto, M., Kano, A., and Maruyama, A., Cationic Graft Copolymer as a DNA B-Z Transition Inducer: Effect of Copolymer Structure. Biomacromolecules, 11, 11, 3043-3048 (2010)
  • 嶋田直彦、丸山厚、生体高分子のフォールディング制御と機能化、高分子, 59(8), 597-600 (2010)

2009年

  • S. Mochizuki, A. Kano, N. Shimada, A. Maruyama, Uptake of enzymatically-digested hyaluronan by endothelial liver cells in vivo and in vitro. J. Biomater. Sci. Polymer Edn., 20, 83-97 (2009)
  • H. Torigoe, A. Maruyama, S. Obika, T. Imanishi, and T. Katayama, Synergistic Stabilization of Nucleic Acid Assembly by 2'-O,4'-C-Methylene-Bridged Nucleic Acid Modification and Additions of Comb-Type Cationic Copolymers. Biochemistry, 48, 3545-3553 (2009)
  • N. Shimada, A. Kano and A. Maruyama, B?Z DNA Transition Triggered by a Cationic Comb-Type Copolymer. Advanced Functional Materials, 19(22), 3590-3595 (2009)
  • Morimoto, N., Tamada, J., Sawada, S., Shimada, N., Kano, A., Maruyama, A., and Akiyoshi, K., Interaction of Self-assembled Cationic Nanogels with Oligo-DNA and Function as Artificial Nucleic Acid Chaperone. Chemistry Letters, 38(5), 496-497 (2009)
  • Chen, J., Tian, H., Guo, Z., Xia, J., Kano, A., Maruyama, A., Jing, X., and Chen, X., A highly efficient siRNA carrier of PBLG modified hyperbranched PEI. Macromol Biosci., 9(12), 1247-53 (2009)
  • Moriyama, R., Shimada, N., Kano, A., and Maruyama, A., Cationic comb-type copolymer as a nucleic acid chaperone for DNA quadruplex. Nucleic Acids Symp Ser., 53, 61-2 (2009)
  • Reddy, T.T., Kano, A., Maruyama, A., Hadano, M., and Takahara, A., Synthesis and characterization of semi-interpenetrating polymer networks based on polyurethane and N-isopropylacrylamide for wound dressing. J Biomed Mater Res B Appl Biomater., 88(1), 32-40 (2009)
  • Shimada, N., Kano, A., and Maruyama, A., Design of cationic graft copolymers as a potential inducer of B-Z transition. Nucleic Acids Symp Ser., 53, 251-2 (2009)
  • Shimada, N., Kano, A., and Maruyama, A., B-Z DNA Transition Triggered by a Cationic Comb-Type Copolymer. Advanced Functional Materials. Advanced Functional Materials, 19(22), 3590-3595 (2009)
  • Thatiparti, T.R., Kano, A., Maruyama, A., and Takahara, A., Novel Silver-Loaded Semi-Interpenetrating Polymer Network Gel Films with Antibacterial Activity. Journal of Polymer Science Part a-Polymer Chemistry, 47(19), 4950-4962 (2009)

2008年

  • S. W. Choi, A. Kano and A. Maruyama, Activation of DNA strand exchange by cationic comb-type copolymers: effect of cationic moieties of the copolymers. Nucleic Acids Res., 36(1), 342-51 (2008)
  • H. Q. Zhang, S. Haga, M. Fukai, Y. Oikawa, H. Inoue, W. Ogawa, A. Kano, A. Maruyama, X. Y. Fu, S. Todo, S. Enosawa and M. Ozaki, Identification of de novo STAT3 target gene in liver regeneration. Hepatol Res., 38(4), 374-384 (2008)
  • T. T. Reddy, A. Kano, A. Maruyama, M. Hadano and A. Takahara, Thermosensitive transparent semi-interpenetrating polymer networks for wound dressing and cell adhesion control. Biomacromolecules, 9(4), 1313-1321 (2008)
  • A. Kano, T. Yamano, S. W. Choi, A. Maruyama, Polymer brush-stabilized polyplex for a siRNA carrier with long blood circulatory half-life. Advanced Materials Research. 47-50, 762-764 (2008)
  • A. Maruyama, L. Wu, N. Shimada and A. Kano, Kinetic Effect of Cationic Comb-type Copolymers on DNA Hybridization, Advanced Materials Research, 47-50, 1355-1358 (2008)

2007

  • Makita, N., Choi, S. W., Kano, A., Yamayoshi, A., Akaike, T., Maruyama, A., Effect of cationic copolymer on quadruplex folding of human telomeric DNA, Nucleosides, Nucleotides Nucleic Acids, 26, 1115-1119 (2007).
  • Choi, S. W., Makita, N., Kano, A., Yamayoshi, A., Akaike, T., Maruyama, A., DNA nanomachine switching improved by cationic comb-type copolymer. Macromol. Symp., 249-250, 317-321 (2007).
  • Choi, S. W., Yamayoshi, A., Hirai, M., Yamano, T., Takagi, M., Sato, A., Kano A., Shimamoto, A., Maruyama, A., Preparation of cationic comb-type copolymers having high density of peg graft chains for gene carriers. Macromol. Symp., 249-250, 312-316 (2007).
  • Choi, S. W., Makita, N., Inoue, S., Lesoil, C., Yamayoshi, A., Kano, A., Akaike, T., Maruyama, A., Cationic comb-type copolymers for boosting DNA-fueled nanomachines. Nano Lett., 7, 172-178 (2007).
  • K. Yamana, Y. Ohshita,Y. Fukunaga, M. Nakamura, A. Maruyama, Bis-Pyrene-Labeled Molecular Beacon: A Monomer-Excimer Switching Probe for the Detection of DNA Base Alteration, Bioorganic & Medicinal Chemistry. (accepted).
  • Sato, Y., Moriyama R., Choi, S. W., Kano, A., Maruyama, A. Spectroscopic investigation of cationic comb-type copolymers/DNA interaction: interpolyelectrolyte complex enhancement synchronized with DNA hybridization. Langmuir, 23, 65-69 (2007).

2006

  • T. Ooya, H. S. Choi, A. Yamashita, N. Yui, Y. Sugaya, A. Kano, A. Maruyama, H. Akita, K. Kogure, H. Harashima, Biocleavable polyrotaxane-plasmid DNA polyplex for enhanced gene delivery, J. Am. Chem. Soc., 128, 3852-3853 (2006).
  • S. Mochizuki, A. Kano, A. Yamayoshi, A. Maruyama, Hyaluronan conjugation of antigenic protein to modify immunogenic information. Science and Technology of Advanced Materials, 7 (7), 685-691(2006).
  • E. H. Chowdhury, A. Maruyama, A. Kano, M. Nagaoka, M. Kotaka, S. Hirose, M. Kuno, T. Akaike, pH-sensing nano-crystals of carbonate apatite: Effects on intracellular deliverty and release of DNA for efficient expression into mammalian cells, Gene, 87-94 (2006).
  • D. Ishii, K. Muraki, A. Kano, A. Yamayoshi, A. Maruyama, Single-base mismatch recognition using partially double-stranded probe having various length, Nucleic Acids. Symp. Ser., 50, 325-326 (2006).
  • Takada, K., Choi, S. W., Yamayoshi, A., Kano, A., Maruyama, A., Structural effect of cationic copolymers on nucleic acid-chaperoning activity. Nucleic Acids Symp. Ser., 50, 27-28 (2006).
  • 新谷彩、丸山厚、人工核酸シャペロン:核酸のハイブリッド形成を促すバイオマテリアル、ウイルスを用いない遺伝子導入法の材料、技術、方法論の新たな展開、原島秀吉、田端泰彦編、遺伝子医学MOOK5pp 240-244 (2006)
  • 山吉麻子、丸山厚、核酸ナノ構造を制御するカチオン性共重合体、未来材料、6(11)10-15(2006)
  • 丸山厚、バイオマテリアルサイエンスと分子生物学との融合による新しい核酸工学、バイオマテリアル、24(2)92-99(2006)

2005

  • H. Torigoe, T. Katayama, S. Obika, A. Maruayma, T. Imanishi, Combination of poly(L-lysine)-graft-dextran copolymer and 2’-O, 4’-C-methylene bridged nucleic acid (2’, 4’-BNA) modification synergistically stabilizes pyrimidine motif triplex at neutral pH, Nucleosides, Nucleotides, and Nucleic Acids, 24, 635-638 (2005)
  • R. Ushijima, N. Sakaguchi, A. Kano, A. Maruyama, Y. Miyamoto, T. Sekimoto, Y. Yoneda, K. Ogino, T. Tachibana, Extracellular signal-dependent nuclear import of STAT3 is mediated by various importin alphas, Biochem. Biophys. Res. Comm., 330, 880-886 (2005).
  • H. Torigoe, A. Maruyama, Synergistic stabilization of nucleic acid assembly by oligo-N3’->P5’ phosphoramidate modification and comb-type cationic copolymer, J. Amer. Chem. Soc., 127, 1705-1710 (2005)
  • Y. Sato, Y. Kobayashi, T. Kamiya, H. Watanabe, T. Akaike, K. Yoshikawa, A. Maruyama, The effect of backbone structure on polycation comb-type copolymer/DNA interactions and the molecular assembly, Biomaterials, 26(7), 703-11 (2005).
  • Choi, S. W., Takada, K., Mochida, J., Yamayoshi, A., Kano, A., Maruyama, A., The molecular structure effect of cationic comb-type copolymers on nucleic acid chaperone activity. Nucleic Acids Symp. Ser., 49, 329-330 (2005).
  • Takei, Yoshiyuki; Ikejima, Kenichi; Enomoto, Nobuyuki; Maruyama, Atsushi; Sato, Nobuhiro.   Genetic manipulation of liver sinusoidal endothelial cells, Keio University International Symposia for Life Sciences and Medicine, 13(Organ Microcirculation), 129-134(2005).
  • K. Yamana,  Y. Fukunaga,  Y. Ohtania,  S. Sato,  M. Nakamura,  W. J. Kim,  T. Akaike, A. Maruyama, DNA mismatch detection using a pyrene? excimer-forming probe, Chem. Commun., 19, 2509-2511 (2005)
  • 丸山厚、カチオン性くし型共重合体の核酸シャペロン機能、図解 高分子新素材のすべて、工業調査会
  • 平田和也、丸山厚、高分子電解質複合体を用いる精密遺伝子診断、高分子、54(8)pp 546-549(2005)
  • 牧田尚樹、丸山厚、DNAで創るナノマシン、現代科学、413pp 55-61(2005)

2004

  • Sung Won Choi, Yuichi Sato, Toshihiro Akaike, Atsushi Maruyama, Preparation of cationic comb-type copolymer having guanidino moieties and its interaction with DNAs, J. Biomater. Sci. Polymer Edn, 15(9), 1099-110 (2004)
  • Ooya Tooru, Yamashita Atsushi, Kurisawa Motoichi, Sugaya Yuko, Maruyama Atsushi, Yui Nobuhiko, Effects of polyrotaxane structure on polyion complexation with DNA, Science and Technology of Advanced Materials, 5, 363-369 (2004)
  • Takei Yoshiyuki, Maruyama Atsushi, Ferdous Anwarul, Nishimura Yoshiya, Kawano Sunao, Ikejima Kenichi, Okumura Shigetoshi, Asayama Shoichiro, Nogawa Masayuki, Hashimoto Masao, Makino Yoko, Kinoshita Masahiko, Watanabe Sumio, Akaike Toshihiro, Lemasters John J., Sato Nobuhiro, argeted gene delivery to sinusoidal endothelial cells: DNA nanoassociate bearing hyaluronan-glycocalyx, FASEB Journal, 18(6), 699-701 (2004).
  • 望月慎一、狩野有宏、赤池敏宏、丸山厚、バイオナノマテリアルとしての多糖コンジュゲート、高分子論文集、61, 601-605 (2004)
  • A. Maruyama, Nucleic acid chaperone-inspired materials, Biomaterials-based delivery and biocompatibility of proteins and nucleic acids, Ed. R. I. Mahato, CRC Press, pp. 601-614 (2004)
  • S. W. Choi, Y. Sato, T. Akaike, A. Maruyama, Evaluation of comb-type copolymers with different cationic groups as artificial nucleic acid chaperones, Nucleic Acids Sym. Ser., No. 48, 273-274 (2004)
  • K. Hirata, Y. Sato, A. Kano, T. Akaike, A. Maruyama, Nucleation-synchronized strand displacement for highly sensitive DNA analysis, Nucleic Acids Sym. Ser., No. 48, 267-268 (2004)
  • T. Katayama, A. Maruyama, S. Obika, T. Imanishi, H, Torigoe, Synergistic stabilization of triplex by combination of comb-type cationic copolymer and 2',4'-BNA, Nucleic Acids Sym. Ser., No. 48, 139-140 (2004)
  • N. Makita, S. Inoue, T. Akaike, A. Maruyama, Improved performance of a DNA nanomachine by cationic copolymers, Nucleic Acids Sym. Ser., No. 48, 173-174, (2004)
  • 丸山厚、核酸工学材料、バイオエンジニアリングマテリアル、石原一彦編、フロンティア出版、pp 216-225 (2004)
  • 丸山厚、遺伝子診断、図解 バイオ活用技術のすべて、東京工業大学生命理工学部編、工業調査会、pp. 106-110 (2004)
  • 丸山厚、糖とDDS、ドラッグデリバリーシステム、19-1, 32-37 (2004)
  • 丸山厚、糖鎖工学、ドラッグデリバリーシステム、19-1, 64 (2004)
  • 丸山厚、赤池敏宏、人工核酸シャペロン、化学フロンティア13(ナノバイオエンジニアリング)、杉本直己編、化学同人、pp 73-83 (2004)

2003

  • W. J. Kim, Yuichi Sato, Toshihiro Akaike, Atsushi Maruyama, Cationic comb-type copolymers for DNA analysis, Nature materials, 2, 815-820 (2003)
  • Kim Won Jong, Sato Yuichi, Akaike Toshihiro, Maruyama Atsushi, Polycation-accelerated strand exchange (PASE) for SNPs typing, Nucleic Acids Research Supplement (2003)
  • K. Tajima, W. J. Kim, Y. Sato, T. Akaike, A. Maruyama, Simple basic peptides activate DNA strand exchange, Chem. Lett. 32, 470-471 (2003)
  • Torigoe Hidetaka, Akaike Toshihiro, Maruyama Atsushi, Rational combination of strategies to achieve synergistic stabilization of triplex, Nucleic Acids Research Supplement (2003)
  • Maruyama Atsushi, Inoue Satoru, Tajima Kaori, Sato Yuichi, Kim Won Jong, Akaike Toshihiro, Design of artificial nucleic acid chaperones for DNA engineering, Nucleic Acids Research Supplement (2003)
  • Sato Yuichi, Kim Won Jon, Saito Minako, Kano Arihiro, Akaike Toshihiro, Maruyama Atsushi, Cationic comb-type copolymers as an artificial nucleic acid chaperone: Spectroscopic analyses for DNA/copolymer interaction, Nucleic Acids Research Supplement (2003)
  • 丸山厚、野川誠之、遺伝子デリバリーシステムでの生体適合性マテリアル、バイオインダストリー、20, 27-33 (2003)
  • 丸山厚、ナノ会合対によるDNAファイバーの機能制御、工業材料、51, 46-49 (2003)
  • 佐藤雄一、丸山厚、遺伝子診断とバイオマテリアル、バイオマテリアル、21, 297-303 (2003)
  • 丸山厚、バイオナノマテリアル、化学装置、45, 39-42 (2003)
  • 丸山厚、合成高分子で核酸のハイブリダイゼーションを操る(レーダー)、化学と教育、51, 360-361 (2003)

2002

  • W. J. Kim, T. Akaike, A. Maruyama, DNA strand exchange stimulated by spontaneous complex formation with cationic comb-type copolymer, J. Am. Chem. Soc., 124, 12676-12677 (2002).
  • Y. Sato, W. J. Kim, S. W. Choi, M. Saito, A. Kano, T. Akaike, A. Maruyama, Investigation of DNA strand exchange mechanisms mediated by cationic polymers, Nucleic Acids Res. Suppl., No. 2, 59-60 (2002).
  • K. Tajima, W. J. Kim, T. Akaike, A. Maruyama, Acceleration of DNA strand exchange reaction by cationic polymers, Nucleic Acids Res. Suppl., No. 2, 265-266 (2002).
  • M. Mikawa, T. Yokawa, N. Miwa, B. Brautigam, T. Akaike, A. Maruyama, An intelligent MRI contrast agent for tumor sensing, Academic Radiology, supple., (2002) in press
  • H. Akashi, H. Kawasaki, W. J. Kim, T. Akaike, K. Taira, A. Maruyama, Enhancement in the cleavage activity of a hammerhead ribozyme by cationic comb-type polymers and an RNA helicase in vitro, J. Biochem.,131, in press (2002)

2001

  • K. Obara, T. Ishihara, T. Akaike, A. MaruyamaProtein/oligonucleotide conjugates as a cell specific PNA carrier, Nucleic Acids Res. Suppl., No. 1, 217-218 (2001).
  • 4. W. J. Kim, T. Akaike, A. Maruyama, Polycation graft copolymers accelerating DNA strand exchange: involvement of ionic interaction, Nucleic Acids Res. Suppl., No. 1, 151-152, (2001).
  • 5. H. Torigoe, T. Akaike. A. Maruyama, Synergistic stabilization of triplex by combination of comb-type cationic copolymer and oligo-N3'->P5' phospharamidates, Nucleic Acids Res. Suppl., No. 1, 195-196 (2001).
  • S. Asayama, T. Akaike, A. Maruyama, Bi-phaseic polycation for the DNA carrier responding to endosomal pH, Colloids Surf. B., 22, 183-191 (2001).
  • M. Nogawa, T. Ishihara, T. Akaike, A. Maruyama, Polyethylenimine/arabinogalactan conjugate as a hepatocyte specific gene carrier, STP Pharma Sci., 11, 97-102 (2001).
  • W. J. Kim, T. Ishihara, T. Akaike, A. Maruyama, Comb-type cationic copolymer expediates DNA strand exchange while stabilizing DNA duplex, Chem. Eur. J., 7, 176-180 (2001).
  • C. S. Cho, A. Kobayashi, R. Takei, T. Ishihara, A. Maruyama, T. Akaike, Receptor-mediated cell modulator delivery to hepatocyte using nanoparticles coated with carbohydrate-carrying polymers, Biomaterials, 22, 45-51 (2001).

2000

  • W. J. Kim, T. Ishihara, T. Akaike, A. Maruyama, Accelaration of DNA strand exchange by polycation comb-type copolymer, Nucleic Acids Sym. Ser., 44, 289-290 (2000).
  • M. Ueda, M. Saito, T. Ishihara T. Akaike, A. Maruyama, Triplex formation using ODN conjugates with polycation comb-type copolymer, Nucleic Acids Sym. Ser., 44, 209-210 (2000).
  • 1 K.-H. Park, M. Goto, R. Takei, A. Maruyama, K. Kobayashi, J. Miyazaki, C.-S. Cho, T. Akaike, Enhanced effect of sulfonylurea(SU) in copolymer comprising a sugar moiety and SU derivative as double ligands on insulin secretion from MIN6 cells, J. Biomater. Sci. Polymer Edn, 11, 903-913 (2000).
  • A. Ferdous, T. Akaike, A. Maruyama, Mechanism of intermolecular purine-purine-pyrimidine triple helix stabilization by comb-type polylysine graft copolymer at physiologic potassium concentration, Bioconjugate Chem., 11, 520-526 (2000).
  • A. Ferdous, T. Akaike, A. Maruyama, Inhibition of sequence-specific protein-DNA interaction and restriction endonuclease cleavage via triplex stabilization by poly(L-lysine)-graft-dextran copolymer, Biomacromolecules, 1, 186-193 (2000).
  • M. Mikawa, N. Miwa, M. Brautigam, T. Akaike, A. Maruyama, Gd3+-loaded polyion complex for pH depiction with magnetic resonance imaging, J. Biomed. Mater. Res., 49, 390-395 (2000).

1999

  • W. J. Kim, T. Ishihara, T. Akaike, A. Maruyama, Acceleration of DNA strand exchange by polycation comb-type copolymer, Nucleic Acids Sym. Ser., 42, 139-140 (1999) .
  • A Maruyama, M. Saito, M. Ueda, H. Watanabe, T. Akaike, Preparation and evaluation of ODN conjugates with polycation comb-type copolymer, Nucleic Acids Sym. Ser., 42, 97-98 (1999).
  • H. Torigoe, T. Akaike, A. Maruyama, Promotion mechanism of triplex DNA formation by comb-type polycations: Thermodynamic analyses of sequence specificity and ionic strength dependence, Nucleic Acids Sym. Ser., 42, 137-138 (1999) .
  • Y. Takei, A. Maruyama, S. Kuwano, Y. Nishimura, S. Asayama, M. Nogawa, K. Ikejima, M. Hori, T. Akaike, J. J. Lemasters, S. Watanabe, N. Sato, Targeted gene transfer to sinusoidal endothelial cells and expression in vivo, Transplant Proc., 790-791 (1999)
  • A. Maruyama, A. Ferdous, T. Ishihara, S. Asayama, J. U. Park, M. Nogawa, H. Watanabe, Y. Takei, T. Akaike, Comb-type copolymers for controlled DNA delivery, Nucleosides Nucleotides, 18, 1681-1682 (1999).
  • J. U. Park, T. Ishihara, A. Kano, T. Akaike, A. Maruyama, Preparation of dendritic graft copolymer consisting of poly(L-lysine) and arabinogaractan as a hepatocyte specific DNA carrier, Prep. Biochem. Biotech., 29, 353-370 (1999).
  • H. Torigoe, A. Ferdous, H. Watanabe, T. Akaike, A. Maruyama, Poly(L-lysine)-graft-dextran copolymer remarkably promotes pyrimidine-motif triplex formation at neutral pH: Thermodynamic and kinetic studies, Nucleoside Nucleotides, 18, 1655-1656 (1999).
  • A. Maruyama, Y. Ohnishi, H. Watanabe, H. Torigoe, A. Ferdous, T. Akaike, Polycation Comb-type copolymer reduces counterion condensation effect to stabilize DNA duplex and triplex formation, Colloids Surf. B, 16, 273-280 (1999).
  • A. Ferdous, H. Watanabe, T. Akaike, A. Maruyama, Relative effects of graft copolymer and polyamines on triplex stabilization under physiological conditions, Nucleoside Nucleotides, 18, 1651-1653 (1999).
  • S. Asayama, A. Maruyama, T. Akaike, Comb-type prepolymers consisting of a polyacrylamide backbone and poly(L-lysine graft chains for multivalent ligands, Bioconjugate Chem., 10, 246-253 (1999).
  • A. Maruyama, T. Ishihara, J. -S. Kim, S. W. Kim, T. Akaike, Design of multi-layered nanoparticles as a DNA carrier, Colloids Surf. A, 153, 439-443 (1999).
  • H. Torigoe, A. Ferdous, H. Watanabe, T. Akaike, A. Maruyama, Poly(l-lysine)-graft-dextran copolymer promotes pyrimidine motif triplex DNA formation at physiological pH. Thermodynamic and kinetic studies. J. Biol. Chem., 274, 6161-6167 (1999).

1998

  • A. Ferdous, H. Watanabe, T. Akaike, A. Maruyama, Comb-type copolymer: Triplex stabilization to compete endonuclease activity, Nucleic Acids Sym. Ser., No. 39, 71-72 (1998).
  • H. Torigoe, A. Ferdous, H. Watanabe, T. Akaike, A. Maruyama, Promotion of pyrimidine-motif triplex formation by poly(L-lysine)-graft-dextran copolymer: Thermodynamic and kinetic studies, Nucleic Acids Sym. Ser., No. 39, 131-132 (1998).
  • A. Maruyama, Y. Kobayashi, H. Watanabe, A. Ferdous, T. Akaike, Promotion of triple helical DNA formation by comb-type polycation copolymers: Influence of polymer structure, Nucleic Acid Sym. Ser., No. 39, 133-134 (1998).
  • A. Ferdous, H. Watanabe, T. Akaike, A. Maruyama, Comb-type copolymer: Stabilization of triplex DNA and possible application in antigene strategy, J. Pharm. Sci., 87, 1400-1405 (1998).
  • A. Ferdous, H. Watanabe, T. Akaike, A. Maruyama, Poly(L-lysine)-graft-dextran copolymer: Amazing effect on triplex stabilization under physiological relevant conditions (in vitro), Nucleic Acids Res., 26, 3949-3954 (1998).
  • S. Asayama, M. Nogawa, Y. Takei, T. Akaike, A. Maruyama, Synthesis of novel polyampholyte comb-type copolymers consisting of poly(L-lysine) backbone and hyaluronic acid side chains for a DNA carrier, Bioconjugate Chem., 9, 476-481 (1998).
  • J. -S. Kim, A. Maruyama, T. Akaike, S. W. Kim, A new non-viral DNA delivery vector: The terplex system, J. Controlled Release, 53, 175-182 (1998).
  • M. Mikawa, N. Miwa, M. Brautigam, T. Akaike, A. Maruyama, A pH-sensitive contrast agent for functional magnetic resonance imaging (MRI), Chem Lett. No. 7, 693-694 (1998).
  • A. Maruyama, H. Watanabe, A. Ferdous, M. Katoh, T. Ishihara, T. Akaike, Characterization of interpolyelectrolyte complexs between double-stranded DNA and polylysine comb-type copolymers having hydrophilic side chains, Bioconjugate Chem., 9, 292-299 (1998).
  • J. -S. Kim, A. Maruyama, T. Akaike, S. W. Kim, Terplex DNA delivery system as a gene carrier, Pharm. Res., 15, 116-121 (1998).

1997年

  • A. Maruyama, H. Watanabe, A. Ferdous, T. Akaike, Poly(L-lysine)-graft-dextran copolymer is a novel stabilizer of triplex DNA(I): Stabilization of poly(dA)2poly(dT) triplex, Nucleic Acid Sym. Ser., No. 37, 225-226 (1997).
  • A. Ferdous, A. Maruyama, H. Watanabe, T. Akaike, Poly(L-lysine)-graft-dextran copolymer is a novel stabilizer of triplex DNA(II): Potassium-insensitive triplex formation, Nucleic Acid Sym. Ser., No. 37, 301-302 (1997)
  • S. Asayama, A. Maruyama, C. -S. Cho, T. Akaike, Design of comb-type polyamine copolymers for a novel pH-sensitive DNA carrier, Bioconjugate Chem., 8, 833-838 (1997).
  • R. Takei, K. -H. Park, H. Ise, A. Maruyama, T. Akaike, Immobilized anti-receptor antibody as an extracellular matrix for liver tissue engineering, Tissue Engineering, 3, 281-288 (1997).
  • A. Maruyama, T. Ishihara, T. Akaike, J. -S. Kim, S. W. Kim, A nanoparticle DNA carrier with poly(L-lysine) grafted polysaccharide copolymer and poly(D, L-lactic acid), Bioconjugate Chem., 8, 735-742 (1997).
  • K. -H. Park, R. Takei, M. Goto, A. Maruyama, A. Kobayashi, K. Kobayashi, T. Akaike, Specific interaction between erythrocyte and glucose carrying polymer mediated by type-1 glucose transporter(GLUT-1) on cell membrane, J. Biochem., 121, 997-1001 (1997).
  • K. Hatanaka, H. Takeshige, A. Maruyama, J. Oishi, Y. Kajihara, H. Hashimoto, New polymeric inhibitor of galactosyl transferase, J. Carbohydr. Chem., 16, 667-672 (1997).
  • J. -S. Kim, A. Maruyama, T. Akaike, S. W. Kim, In vitro gene expression on smooth muscle cells using a terplex delivery system, J. Contr. Rel, 47, 51-59 (1997).
  • A. Maruyama, M. Katoh, T. Ishihara, T. Akaike, Comb-type polycations effectively stabilize DNA triplex, Bioconjugate Chem., 8, 3-6 (1997).
  • C. S. Cho, Y. I. Jeong, T. Ishihara, R. Takei, J. U. Park, K. H. Park, A. Maruyama, T. Akaike, Simple preparation of nanoparticles coated with carbohydrate-carrying polymers, Biomaterials, 18, 323-326 (1997)

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